Chai
Structure prediction and de novo binder design aimed at drug programs.
Full Chai record →Head to head
Chai vs ESM3
Chai (Chai Discovery) and ESM3 (EvolutionaryScale) both sit in Science & Bio. Chai shipped more tracked changes in the last 30 days (8 vs 3). Every value below comes from the latest crawl of the vendors' own pages.
| Attribute | Chai Chai Discovery | ESM3 EvolutionaryScale |
|---|---|---|
| Segment | Science & Bio | Science & Bio |
| Version | Chai-1 | ESM3 |
| Entry cost | Pricing is not publicly listed (enterprise/licensing) | ESM3-open is free on GitHub. Other ESM3 model sizes are available via the Biohub Platform API (pricing not listed). |
| Pricing tiers | — | ESM3-open free |
| Model stack | Chai · Chai biological models · Chai-1 · Chai-2 | ESM Cambrian · ESM3 · ESM3 (98B) · ESM3 (Large) · ESM3 (Medium) · ESM3 (Small) · ESM3-open |
| Context window | — | — |
| Public API | ||
| Routes models | ||
| Changes / 30d | 8 | 3 |
| Origin | United States | United States |
| Capabilities | De novo binders, Complex prediction, Antibody design, Web tool, drug discovery, molecule design, antibody discovery, molecular design | Protein generation, Sequence-structure-function, Open weights, Forge API, sequence modeling, structure generation, function design, protein generation |
ESM3
Generative protein model that reasons jointly over sequence, structure and function.
Full ESM3 record →