Lila Sciences
Lila SciencesUnited States
10
Autonomous science factories
- Version
- LILA
- Cost
- Pricing is not publicly disclosed. Contact Lila Sciences for custom enterprise solutions.
- Model
- LILA
ESM3
EvolutionaryScale · #7 most active of 8 in Science & Bio
Generative protein model that reasons jointly over sequence, structure and function.
100
Trust score · Verified
2 data points checked · 2026-09-07
Current version
ESM3
Entry cost
Available through the Biohub Platform API, with an open-source version (ESM3-open) available on GitHub.
Changes / 30d
3
The short answers · verified September 12, 2026
- What is the latest version of ESM3?
- The current shipped version of ESM3 is ESM3, as of September 12, 2026.
- How much does ESM3 cost?
- ESM3 has no published flat entry price. Available through the Biohub Platform API, with an open-source version (ESM3-open) available on GitHub.
- What AI model does ESM3 use?
- ESM3 runs primarily on ESM Cambrian.
Source: EvolutionaryScale — www.evolutionaryscale.ai · Reusable under CC BY 4.0 — cite Tomorrow
Capabilities
- Protein generation
- Sequence-structure-function
- Open weights
- Forge API
- sequence modeling
- structure generation
- function design
- protein generation
- chain-of-thought prompting
- generative protein design
- sequence, structure, and function reasoning
- representation learning
- structure modeling
- function modeling
- Sequence design
- Structure design
- Function design
- Chain-of-thought prompting
- Generative protein design
- Sequence, structure, and function reasoning
- Representation learning
- structure reasoning
- function reasoning
- Sequence modeling
- Structure modeling
- Function modeling
- protein sequence modeling
- multimodal reasoning (sequence, structure, function)
- structure prediction
- functional prompting
- multi-modal reasoning (sequence, structure, function)
- protein design
- sequence generation
- functional annotation
- reasoning over sequence, structure, and function
- generative biology
- sequence structure and function reasoning
- Sequence reasoning
- Structure reasoning
- Function reasoning
- functional prediction
- protein modeling
- generative
- functional modeling
- multimodal reasoning
- generative design
Pricing
ESM3-open (GitHub)
Available under a non-commercial license
Free
Forge API / Closed Beta
Pricing not disclosed. Apply for access.
Free
Entry price over time
Geek mode
Models under the hood
- disclosed
ESM Cambrian
EvolutionaryScale
- disclosed
ESM3
EvolutionaryScale
- disclosed
ESM3 (Large)
EvolutionaryScale
- disclosed
ESM3 (Medium)
EvolutionaryScale
- disclosed
ESM3 (Small)
EvolutionaryScale
- disclosed
ESM3-open
EvolutionaryScale
Context window
—
Public API
yes
Multi-model routing
yes
Shared model stack
Other tracked products running on the same foundation models — a quick read on how much of the catalog moves when one of these models changes.
- ESM CambrianEvolutionaryScale · 1 product
- ESM3EvolutionaryScale · 1 product
- ESM3 (Large)EvolutionaryScale · 1 product
- ESM3 (Medium)EvolutionaryScale · 1 product
- ESM3 (Small)EvolutionaryScale · 1 product
- ESM3-openEvolutionaryScale · 1 product
green disclosed · amber inferred · grey unattributed. Aliases are folded into one model; provider concentration counts only models with an established vendor.
Reported scale
Reference data. Each figure is whatever the source actually said — weekly users, downloads, revenue run-rate — with its own definition and date. These are not comparable between tools and are never used to rank anything.
No public usage figure on record for this product.
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Change history
- capability
- capability
- capability
New capabilities: generative, functional modeling
42 tracked44 tracked · +generative, functional modeling
source - capability
- capability
- capability
New capabilities: Sequence reasoning, Structure reasoning, Function reasoning
37 tracked40 tracked · +Sequence reasoning, Structure reasoning, Function reasoning
source - capability
New capabilities: sequence structure and function reasoning
36 tracked37 tracked · +sequence structure and function reasoning
source - capability
- capability
New capabilities: reasoning over sequence, structure, and function
34 tracked35 tracked · +reasoning over sequence, structure, and function
source - capability
New capabilities: protein design, sequence generation, functional annotation
31 tracked34 tracked · +protein design, sequence generation, functional annotation
source - capability
New capabilities: multi-modal reasoning (sequence, structure, function)
30 tracked31 tracked · +multi-modal reasoning (sequence, structure, function)
source - capability
New capabilities: structure prediction, functional prompting
28 tracked30 tracked · +structure prediction, functional prompting
source - capability
New capabilities: protein sequence modeling, multimodal reasoning (sequence, structure, function)
26 tracked28 tracked · +protein sequence modeling, multimodal reasoning (sequence, structure, function)
source - capability
New capabilities: Sequence modeling, Structure modeling, Function modeling
23 tracked26 tracked · +Sequence modeling, Structure modeling, Function modeling
source - capability
New capabilities: structure reasoning, function reasoning
21 tracked23 tracked · +structure reasoning, function reasoning
source - model
ESM3 added ESM3-Large, ESM3-Medium, ESM3-Small to its model stack
ESM Cambrian, ESM3, ESM3-openESM Cambrian, ESM3, ESM3-Large, ESM3-Medium, ESM3-Small, ESM3-open
source - capability
New capabilities: Generative protein design, Sequence, structure, and function reasoning, Representation learning
18 tracked21 tracked · +Generative protein design, Sequence, structure, and function reasoning, Representation learning
source - capability
New capabilities: Sequence design, Structure design, Function design
14 tracked18 tracked · +Sequence design, Structure design, Function design, Chain-of-thought prompting
source - capability
New capabilities: structure modeling, function modeling
12 tracked14 tracked · +structure modeling, function modeling
source - capability
New capabilities: generative protein design, sequence, structure, and function reasoning, representation learning
9 tracked12 tracked · +generative protein design, sequence, structure, and function reasoning, representation learning
source - model
- capability
New capabilities: sequence modeling, structure generation, function design
4 tracked9 tracked · +sequence modeling, structure generation, function design, protein generation, chain-of-thought prompting
source - model
ESM3 added ESM3 (Small, Medium, Large) to its model stack
ESM Cambrian, ESM3, ESM3-openESM Cambrian, ESM3, ESM3 (Small, Medium, Large), ESM3-open
source - capability
New capabilities: sequence generation, structure generation, functional prediction
5 tracked8 tracked · +sequence generation, structure generation, functional prediction
source - capability
New capabilities: protein design, representation learning, generative biology
5 tracked8 tracked · +protein design, representation learning, generative biology
source - capability
New capabilities: sequence modeling, structure modeling, function modeling
6 tracked10 tracked · +sequence modeling, structure modeling, function modeling, generative protein design
source - capability
New capabilities: protein generation, chain-of-thought prompting
6 tracked8 tracked · +protein generation, chain-of-thought prompting
source - capability
New capabilities: sequence reasoning, structure reasoning, function reasoning
5 tracked8 tracked · +sequence reasoning, structure reasoning, function reasoning
source - model
ESM3 added ESM Cambrian, ESM3 to its model stack
ESM3-large, ESM3-medium, ESM3-open, ESM3-smallESM Cambrian, ESM3, ESM3-large, ESM3-medium, ESM3-open, ESM3-small
source - capability
New capabilities: protein sequence modeling, representation learning, generative protein design
5 tracked9 tracked · +protein sequence modeling, representation learning, generative protein design, reasoning over sequence, structure, function
source - model
ESM3 added ESM3-large, ESM3-medium, ESM3-small to its model stack
ESM Cambrian, ESM3, ESM3-openESM Cambrian, ESM3, ESM3-large, ESM3-medium, ESM3-open, ESM3-small
source - capability
New capabilities: protein generation, sequence modeling, structure modeling
7 tracked11 tracked · +protein generation, sequence modeling, structure modeling, function modeling
source - capability
New capabilities: representation learning, generative protein design, chain-of-thought prompting
4 tracked11 tracked · +representation learning, generative protein design, chain-of-thought prompting, multimodal reasoning, sequence prediction, structure prediction, function prediction
source - model
- capability
New capabilities: Generative protein design, Chain-of-thought prompting, Multimodal reasoning (sequence, structure, function)
4 tracked8 tracked · +Generative protein design, Chain-of-thought prompting, Multimodal reasoning (sequence, structure, function), Representation learning
source - model
ESM3 added ESM3 to its model stack
ESM3 Large, ESM3 Medium, ESM3 Small, ESM3-openESM3, ESM3 Large, ESM3 Medium, ESM3 Small, ESM3-open
source - capability
New capabilities: protein generation, sequence reasoning, structure reasoning
3 tracked7 tracked · +protein generation, sequence reasoning, structure reasoning, function reasoning
source - capability
New capabilities: Generative protein design, Sequence, structure, and function reasoning, Chain-of-thought prompting
4 tracked7 tracked · +Generative protein design, Sequence, structure, and function reasoning, Chain-of-thought prompting
source
ESM3 compared
Straight head-to-head pages against the busiest products in Science & Bio.
How to cite this page
Free to cite and reuse under CC BY 4.0. Permalink: https://tomorrow.aliensquad.ai/tools/esm3
APA
Tomorrow. (2026). ESM3 — version, pricing and model stack [Data set entry]. AlienSquad. Retrieved 2026-09-13, from https://tomorrow.aliensquad.ai/tools/esm3
BibTeX
@misc{tomorrow-tools-esm3,
author = {{Tomorrow}},
title = {ESM3 — version, pricing and model stack},
year = {2026},
publisher = {AlienSquad},
howpublished = {\url{https://tomorrow.aliensquad.ai/tools/esm3}},
note = {Accessed: 2026-09-13}
}