Chai
Chai DiscoveryUnited States
8
Antibody and complex design
- Version
- Chai-1
- Cost
- Pricing is not publicly listed (enterprise/licensing)
- Model
- Chai-1
ESM3
EvolutionaryScale · #7 most active of 8 in Science & Bio
Generative protein model that reasons jointly over sequence, structure and function.
100
Trust score · Verified
2 data points checked · 2026-11-04
Current version
ESM3
Entry cost
ESM3-open is free on GitHub. Other ESM3 model sizes are available via the Biohub Platform API (pricing not listed).
Changes / 30d
3
The short answers · verified November 7, 2026
- What is the latest version of ESM3?
- The current shipped version of ESM3 is ESM3, as of November 7, 2026.
- How much does ESM3 cost?
- ESM3 has no published flat entry price. ESM3-open is free on GitHub. Other ESM3 model sizes are available via the Biohub Platform API (pricing not listed).
- What AI model does ESM3 use?
- ESM3 runs primarily on ESM Cambrian.
Source: EvolutionaryScale — www.evolutionaryscale.ai · Reusable under CC BY 4.0 — cite Tomorrow
Capabilities
- Protein generation
- Sequence-structure-function
- Open weights
- Forge API
- sequence modeling
- structure generation
- function design
- protein generation
- chain-of-thought prompting
- generative protein design
- sequence, structure, and function reasoning
- representation learning
- structure modeling
- function modeling
- Sequence design
- Structure design
- Function design
- Chain-of-thought prompting
- Generative protein design
- Sequence, structure, and function reasoning
- Representation learning
- structure reasoning
- function reasoning
- Sequence modeling
- Structure modeling
- Function modeling
- protein sequence modeling
- multimodal reasoning (sequence, structure, function)
- structure prediction
- functional prompting
- multi-modal reasoning (sequence, structure, function)
- protein design
- sequence generation
- functional annotation
- reasoning over sequence, structure, and function
- generative biology
- sequence structure and function reasoning
- Sequence reasoning
- Structure reasoning
- Function reasoning
- functional prediction
- protein modeling
- generative
- functional modeling
- multimodal reasoning
- generative design
- sequence structure function reasoning
- functional design
- sequence prediction
- function prediction
- reasoning over sequence structure function
- sequence reasoning
- generative AI
- reasoning over sequence, structure, function
- protein structure prediction
- Generative AI
- Protein Sequence Modeling
- Representation Learning
- Open weights (ESM3-open)
- open source weights
- Sequence prediction
- Structure prediction
- Function prediction
- Generative biology
- Protein design
- Protein sequence modeling
- Generative design
- function generation
- Generative Protein Design
- Structure Reasoning
- Function Reasoning
- API Access
- Open Weights Model
- Sequence generation
- Structure generation
- Function generation
- API access
- Open source weights (ESM3-open)
- sequence-to-structure
- open weights
- Open weights model (ESM3-open)
- api access
- open weights (ESM3-open)
- Generative protein modeling
Pricing
ESM3-open
Weights and source code available on GitHub under an MIT license
Free
Entry price over time
Geek mode
Models under the hood
- disclosed
ESM Cambrian
EvolutionaryScale
- disclosed
ESM3
EvolutionaryScale
- disclosed
ESM3 (98B)
EvolutionaryScale
- disclosed
ESM3 (Large)
EvolutionaryScale
- disclosed
ESM3 (Medium)
EvolutionaryScale
- disclosed
ESM3 (Small)
EvolutionaryScale
- disclosed
ESM3-open
EvolutionaryScale
Context window
—
Public API
yes
Multi-model routing
yes
Shared model stack
Other tracked products running on the same foundation models — a quick read on how much of the catalog moves when one of these models changes.
- ESM CambrianEvolutionaryScale · 1 product
- ESM3EvolutionaryScale · 1 product
- ESM3 (98B)EvolutionaryScale · 1 product
- ESM3 (Large)EvolutionaryScale · 1 product
- ESM3 (Medium)EvolutionaryScale · 1 product
- ESM3 (Small)EvolutionaryScale · 1 product
- ESM3-openEvolutionaryScale · 1 product
green disclosed · amber inferred · grey unattributed. Aliases are folded into one model; provider concentration counts only models with an established vendor.
Reported scale
Reference data. Each figure is whatever the source actually said — weekly users, downloads, revenue run-rate — with its own definition and date. These are not comparable between tools and are never used to rank anything.
No public usage figure on record for this product.
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Change history
- model
ESM3 added ESM3 (98B) to its model stack
ESM Cambrian, ESM3, ESM3 (Large), ESM3 (Medium), ESM3 (Small), ESM3-openESM Cambrian, ESM3, ESM3 (98B), ESM3 (Large), ESM3 (Medium), ESM3 (Small), ESM3-open
source - capability
New capabilities: Generative protein modeling
83 tracked84 tracked · +Generative protein modeling
source - capability
New capabilities: api access, open weights (ESM3-open)
81 tracked83 tracked · +api access, open weights (ESM3-open)
source - capability
New capabilities: Open weights model (ESM3-open)
80 tracked81 tracked · +Open weights model (ESM3-open)
source - capability
- capability
- capability
New capabilities: Open source weights (ESM3-open)
77 tracked78 tracked · +Open source weights (ESM3-open)
source - capability
- capability
New capabilities: Sequence generation, Structure generation, Function generation
73 tracked76 tracked · +Sequence generation, Structure generation, Function generation
source - capability
New capabilities: Generative Protein Design, Structure Reasoning, Function Reasoning
68 tracked73 tracked · +Generative Protein Design, Structure Reasoning, Function Reasoning, API Access, Open Weights Model
source - capability
- capability
New capabilities: Protein sequence modeling, Generative design
65 tracked67 tracked · +Protein sequence modeling, Generative design
source - capability
New capabilities: Sequence prediction, Structure prediction, Function prediction
60 tracked65 tracked · +Sequence prediction, Structure prediction, Function prediction, Generative biology, Protein design
source - capability
- capability
- capability
New capabilities: Generative AI, Protein Sequence Modeling, Representation Learning
55 tracked58 tracked · +Generative AI, Protein Sequence Modeling, Representation Learning
source - capability
New capabilities: protein structure prediction
54 tracked55 tracked · +protein structure prediction
source - capability
New capabilities: reasoning over sequence, structure, function
53 tracked54 tracked · +reasoning over sequence, structure, function
source - capability
- capability
- capability
New capabilities: reasoning over sequence structure function
50 tracked51 tracked · +reasoning over sequence structure function
source - capability
New capabilities: sequence prediction, function prediction
48 tracked50 tracked · +sequence prediction, function prediction
source - capability
- capability
New capabilities: sequence structure function reasoning
46 tracked47 tracked · +sequence structure function reasoning
source - capability
- capability
- capability
New capabilities: generative, functional modeling
42 tracked44 tracked · +generative, functional modeling
source - capability
- capability
- capability
New capabilities: Sequence reasoning, Structure reasoning, Function reasoning
37 tracked40 tracked · +Sequence reasoning, Structure reasoning, Function reasoning
source - capability
New capabilities: sequence structure and function reasoning
36 tracked37 tracked · +sequence structure and function reasoning
source - capability
- capability
New capabilities: reasoning over sequence, structure, and function
34 tracked35 tracked · +reasoning over sequence, structure, and function
source - capability
New capabilities: protein design, sequence generation, functional annotation
31 tracked34 tracked · +protein design, sequence generation, functional annotation
source - capability
New capabilities: multi-modal reasoning (sequence, structure, function)
30 tracked31 tracked · +multi-modal reasoning (sequence, structure, function)
source - capability
New capabilities: structure prediction, functional prompting
28 tracked30 tracked · +structure prediction, functional prompting
source - capability
New capabilities: protein sequence modeling, multimodal reasoning (sequence, structure, function)
26 tracked28 tracked · +protein sequence modeling, multimodal reasoning (sequence, structure, function)
source - capability
New capabilities: Sequence modeling, Structure modeling, Function modeling
23 tracked26 tracked · +Sequence modeling, Structure modeling, Function modeling
source - capability
New capabilities: structure reasoning, function reasoning
21 tracked23 tracked · +structure reasoning, function reasoning
source - model
ESM3 added ESM3-Large, ESM3-Medium, ESM3-Small to its model stack
ESM Cambrian, ESM3, ESM3-openESM Cambrian, ESM3, ESM3-Large, ESM3-Medium, ESM3-Small, ESM3-open
source
ESM3 compared
Straight head-to-head pages against the busiest products in Science & Bio.
How to cite this page
Free to cite and reuse under CC BY 4.0. Permalink: https://tomorrow.aliensquad.ai/tools/esm3
APA
Tomorrow. (2026). ESM3 — version, pricing and model stack [Data set entry]. AlienSquad. Retrieved 2026-11-08, from https://tomorrow.aliensquad.ai/tools/esm3
BibTeX
@misc{tomorrow-tools-esm3,
author = {{Tomorrow}},
title = {ESM3 — version, pricing and model stack},
year = {2026},
publisher = {AlienSquad},
howpublished = {\url{https://tomorrow.aliensquad.ai/tools/esm3}},
note = {Accessed: 2026-11-08}
}