ESM3
Generative protein model that reasons jointly over sequence, structure and function.
Full ESM3 record →Head to head
ESM3 vs Boltz
ESM3 (EvolutionaryScale) and Boltz (MIT) both sit in Science & Bio. Boltz shipped more tracked changes in the last 30 days (5 vs 3). Every value below comes from the latest crawl of the vendors' own pages.
| Attribute | ESM3 EvolutionaryScale | Boltz MIT |
|---|---|---|
| Segment | Science & Bio | Science & Bio |
| Version | ESM3 | Boltz-2 |
| Entry cost | ESM3-open is free on GitHub. Other ESM3 model sizes are available via the Biohub Platform API (pricing not listed). | Pricing is not published. API and Enterprise deployments available. |
| Pricing tiers | ESM3-open free | — |
| Model stack | ESM Cambrian · ESM3 · ESM3 (98B) · ESM3 (Large) · ESM3 (Medium) · ESM3 (Small) · ESM3-open | Boltz-2 · BoltzGen · BoltzMol-1 · BoltzProt-1 |
| Context window | — | — |
| Public API | ||
| Routes models | ||
| Changes / 30d | 3 | 5 |
| Origin | United States | United States |
| Capabilities | Protein generation, Sequence-structure-function, Open weights, Forge API, sequence modeling, structure generation, function design, protein generation | Open weights, Affinity prediction, Complex structures, Local inference, Design small molecules, Design proteins, Predict structures, Fine-tuning |
Boltz
Open-source, AlphaFold3-class biomolecular structure and affinity prediction.
Full Boltz record →